WebJun 25, 2024 · Recent clinical data demonstrated that BRD4 is a valuable target for treating glioma. 47 Interestingly, BRD4 inhibitors effectively penetrate the blood-brain barrier (BBB) 46,48,49 and target glioma tumor tissues, while having have little effects on normal brain tissue. 46 BRD4 expression in glioma WebNov 4, 2024 · BRD4 is considered a therapeutic target of tamoxifen-resistant breast cancer ( 81) because it participates in the regulation of ERα function ( 82, 83 ). In basal-like breast cancer, BRD4 links nonhistone Twist diacetylation to tumorigenesis ( 84 ). Moreover, there is a bromodomain-independent effect of BRD4 in BET-resistant TNBC cells ( 85 ).
Enhancer RNAs (eRNAs) in Cancer: The Jacks of All Trades
WebDec 5, 2024 · BRD4 assembles transcriptional machinery at gene super-enhancer regions and governs the expression of genes that are critical for cancer … WebAug 8, 2024 · Indeed, BRD4 inhibitor has been proved to significantly suppress proliferation and promoted apoptosis in many tumours [43,44,45,46], including triple-negative breast cancer . However, it is noteworthy that targeting SEs when using BETi for cancer treatment might cause significant side effects because some tumor suppressor genes will also be ... how to make a computer in scratch
BRD4 Regulates EZH2 Transcription through Upregulation of C …
WebMay 4, 2024 · Breast cancer (BC) affects the breast tissue and easily metastasizes to the bones and lungs. Globally, BC has very high incidence rates1. It is the second most common cause of mortalities among women2, accounting for an estimated 24% of diagnosed cases and 15% of mortality cases among them3. WebJun 18, 2024 · With BRD4 isoform-specific antibodies and knockdown and mouse xenograft and transgene expression, Wu et al. demonstrate oncogenic BRD4-S and tumor … WebApr 29, 2008 · Intriguingly, the Brd4 signature also almost perfectly matches a molecular classifier of low-grade tumors. Taken together, these data suggest that dysregulation of … how to make a computer discovered on network