Ctbp1是什么

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August undefined, 2024

CTBP1 - Wikipedia

WebAug 14, 2024 · The phenotype of Ctbp1/2 DKO in ground-state ESCs resembles that of Klf2 KO ESCs cultured in 2i (Yeo et al., 2014). There was an abnormal upregulation of PGC markers in Klf2 KO ESCs under 2i conditions. In contrast, the expression of PGC-markers in Ctbp1/2 DKO ESCs were similar to those in wild-type ESCs under the 2i plus LIF … WebCtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely … billy steinberg songwriter

A pathogenic CtBP1 missense mutation causes altered cofactor

WebCtBP1 proteins are identifiable as a single band on Western blots and are ubiquitously detectable in breast tumour samples, by both Western blotting and immunohistochemistry. CtBP1 is present in six of six breast cancer cell lines, although it is barely detectable in SKBr3 cells due to reduced CTBP1 mRNA expression. In the cell lines, the ... WebOrthologous to human CTBP1 (C-terminal binding protein 1) and CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2024] CtBP C-terminal Binding Protein [ (fruit fly)] Gene ID: 41602, updated on 5-Jan-2024. Summary. Enables several functions, including protein homodimerization activity; transcription … WebApr 9, 2024 · CtBP1 represses Brca1 transcription by binding to the E2F4 site of the Brca1 promoter. The recruitment of CtBP1 to the Brca1 promoter increased at high NADH … billy stephens

CtBP1/2 differentially regulate genomic stability and DNA …

WebC-terminal binding proteins (CtBP1/2) are transcriptional coregulators that play a significant role during vertebrate neurodevelopment. This systematic review aims to identify case reports with genetic variants in CTBP1 and CTBP2 associated with brain development syndromes.We screened different databases (PubMed, Scopus, Google Scholar, … WebCTBP1-AS is an androgen-responsive lncRNA involved in the regulatory epigenetic network in prostate cancer, which functions in response to androgens [24]. Its expression is … cynthia dresserWebCtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important co-repressors for a variety of transcriptional factors. Purified Mouse Anti-CtBP2 ... billy stepney

"WebJan 27, 2011 · Abstract. Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that represses expression of various tumor suppressor genes. In the present study, we identified miR-137 as a potential regulator of CtBP1 expression in melanoma cells. Expression of miR-137 in melanoma cell lines was found to inversely correlate with … " - Ctbp1是什么

Ctbp1是什么

CtBP Antibody (E-12) SCBT - Santa Cruz Biotechnology

http://www.cancerindex.org/geneweb/CTBP1.htm WebNov 11, 2024 · 好了，该说说PGC-1α这个蛋白了。. 这个蛋白在棕色脂肪细胞和白色脂肪细胞里面都有，不过前者的量远远大于后者。. 在体内的棕色脂肪细胞如果受到冷刺激或者 …

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WebApr 6, 2024 · CPC = cost per click 单次点击价格. CPM = cost per mile 千次展示收益（收益是对广告平台来说的）. CTR = click through rate 点击率. 那为什么这三个指标会一起说呢？. 其实一般有这个公式 : CPM = ACP * CTR. 那ACP又是什么呢？. ACP = cost/Click （其 … WebCTBP1 is a cellular phosphoprotein that associates with various proteins and functions as a corepressor of transcription. CTBP1 and the related protein CTBP2 are characterized as …

WebSep 27, 2024 · Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome (HADDTS) is an extremely rare autosomal dominant genetic disease caused by disruptive pathogenic variants in CTBP1. There are merely 12 cases reported to have pathogenic variants in the CTBP1 gene. Here, we report the first case with HADDTS in the Middle … WebOct 25, 2024 · BACKGROUND Recent studies have illustrated that the transcription co-repressor, C-terminal binding protein 1 (CtBP1), links the metabolic alterations to transcription controls in proliferation, EMT, genome stability, metabolism, and lifespan, but whether CtBP1 affects the cellular redox homeostasis is unexplored.

WebCtBP family proteins are unique in animals and in plants. The invertebrates and plants contain a single CtBP family gene while vertebrates have two genes. Genetic studies in Drosophila and in mice indicate that CtBPs play pivotal roles in animal development. The vertebrate CtBPs (CtBP1 and CtBP2) are highly related and are functionally redundant … WebBeck et al. (2016) reported 4 unrelated patients, ranging in age from 8 to 20 years, with a similar complex neurodevelopmental disorder. The patients had hypotonia and variably delayed motor development: 2 patients were nonambulatory at ages 12 and 20 years, whereas the others learned to walk in the first years of life but had an ataxic gait.

WebWithin this cohort, we identified consistent CtBP1-related phenotypes of intellectual disability, ataxia, hypotonia, and tooth enamel defects present in most patients. The … billy stephensonWebCtBP family proteins are unique in animals and in plants. The invertebrates and plants contain a single CtBP family gene while vertebrates have two genes. Genetic studies in … billy step ixellesWebFunction [ edit] The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein … billy stergiouWebOct 27, 2024 · A recurrent de novo mutation in the transcriptional corepressor CTBP1 is associated with neurodevelopmental disabilities in children (Beck et al., 2016, 2024; Sommerville et al., 2024). All reported patients harbor a single recurrent de novo heterozygous missense mutation (p.R342W) within the cofactor recruitment domain of … cynthia drexlerWebMar 21, 2024 · Long non‑coding RNA CTBP1‑AS2 upregulates USP22 to promote pancreatic carcinoma progression by sponging miR‑141‑3p. (PMID: 35039872) Zhang M … Ma J (Molecular medicine reports 2024) 3 138; Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4. cynthia dressWebCtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the δEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction ... billy stevenson elementaryWebJan 15, 2024 · CtBP Antibody (E-12) is an IgG 1 κ mouse monoclonal CtBP antibody (also designated CTBP1/2 antibody) suitable for the detection of the CtBP protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. CtBP Antibody (E-12) is available as both the non-conjugated anti-CtBP antibody form, as well as multiple conjugated forms of … billy stewart antrim