Dimethylarsino-cysteine
WebJun 13, 2005 · This compound belongs to the class of organic compounds known as l-cysteine-s-conjugates. These are compounds containing L-cysteine where the thio … WebS-dimethylarsino-cysteine (DMAC). Data shows that rapid thiolate exchange of dimethylarsonim, Me 2 As+, occurs when the two compounds are dissolved in aqueous solution. The equilibrium constants of this interthiol transfer were characterised by the integrals of the diastereotopic ...
Dimethylarsino-cysteine
Did you know?
WebIn the field of enzymology, a dimethylargininase, also known as a dimethylarginine dimethylaminohydrolase ( DDAH ), is an enzyme that catalyzes the chemical reaction : N … WebAug 1, 2004 · The trivalent arsenosugar was readily formed by reaction of the pentavalent arsenosugar with thiol compounds, including, cysteine, glutathione, and dithioerythritol. This work suggests that the reduction of pentavalent arsenosugars to trivalent arsenosugars in biology might have environmental consequences, especially because seaweed …
WebThe meaning of DIMETHYLNITROSAMINE is a carcinogenic nitrosamine C2H6N2O that occurs especially in tobacco smoke.
WebFeb 15, 2024 · Furthermore, it has been shown that [DMA III (GS)] is degraded by γ-GT (gamma-glutamyltransferase) and subsequently by di-peptidase dissociating S-dimethylarsino-cysteine (DMAC) [7]. In this context, DMAC has a favorable conformation for transport through cystine/cysteine transporters such as xCT and xAG [7]. WebJun 20, 2006 · Request PDF Phase-1 trial of ZIO-101, a novel organic arsenic in patients with advanced cancers 13041 Background: Arsenics are potent anti-cancer drugs. Organic arsenics are much less toxic ...
WebDarinaparsin (Dar; ZIO-101; S-dimethylarsino-glutathione) is a promising novel organic arsenical currently undergoing clinical studies in various malignancies. Dar consists of dimethylarsenic conjugated to glutathione (GSH). Dar induces more intracellular arsenic accumulation and more cell death than the FDA-approved arsenic trioxide (ATO) in vitro, …
WebApr 1, 2014 · Darinaparsin (Dar; ZIO-101; S -dimethylarsino-glutathione) is a promising novel organic arsenical currently undergoing clinical studies in various … columbia county ny car break insWebNov 28, 1983 · Chemical studies showed that S-dimethylarsino-CoA reacts with the thiol of N α-acetylcysteine but not with the side-chain functional groups of histidine and lysine. … columbia county ny district attorney\u0027s officeWebMar 27, 2015 · COMMENTARY COMMENTARY Systems approach to metal- based pharmacology Isolda Romero-Caneln and Peter J. Sadler1 There is an abundance of thiolate sulfur in Department of Chemistry, University of Warwick, Coventry CV4 7AL, United Kingdom cells. Most cells contain 214 mM glutathi- one, the tripeptide -L-glutamyl-L … columbia county mls listingsWebS-(Dimethylarsenic)Cysteine. Molecular Formula C 5 H 12 AsNO 2 S; Average mass 225.141 Da; Monoisotopic mass 224.980469 Da; ChemSpider ID 26330162 dr thomas huggettWebJun 13, 2005 · This compound belongs to the class of organic compounds known as l-cysteine-s-conjugates. These are compounds containing L-cysteine where the thio-group is conjugated. Kingdom Organic compounds Super Class Organic acids and derivatives Class Carboxylic acids and derivatives Sub Class Amino acids, peptides, and analogues Direct … columbia county ny department of healthWebMay 31, 2014 · Cysteine conjugates produced by dipeptidases or amino peptidases following the GST and yGT steps, are transformed by cysteine conjugate P-lyases present in the cytosol and mitochondria. The P-lyases catalyze the P-elimination of various L-cysteine ^-conjugates to the corresponding thiols (Cooper, 1998). columbia county ny dmv appointmentsWebFeb 6, 2006 · New organic arsenic derivatives have been synthesized, including S-dimethylarsino-glutathione, S-dimethylarsino-thiosuccinic acid and S-dimethylarsino-thiobenzoic acid, and established its potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against … dr thomas huggett chicago