WebPin1, a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2/M transition of the mammalian cell cycle (1-6). Pin1 is a small (18 kDa) protein with two distinct functional domains: an amino-terminal WW domain and a carboxy-terminal PPlase domain. Pin1 interacts with several mitotic phosphoproteins ...
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WebAug 7, 2024 · Each of these domains facilitates interactions between MYC and a diverse set of binding partners in order to regulate MYC function and gene target specificity. The MB0-II domains are essential to MYC protein stability and activity, and facilitate MYC’s association with co-factors, such as PIN1, FBW7, and P-TEFb [19, 22–26]. WebIn addition to inducing PIN1 protein degradation, ATRA has been found to increase the cellular uptake of another PIN1 inhibitor, arsenic trioxide (ATO), in breast cancer cells through up-regulation of cell membrane arsenic transporter aquaporin 9 (Leung et al., 2007; Kozono et al., 2024). ATO is another FDA approved drug used for the treatment ...
WebDec 12, 1997 · Pin1, originally isolated as a protein that interacts with and inhibits the essential mitotic kinase NIMA, is highly conserved and possesses both a WW domain and PPIase activity ().PPIases catalyze the relatively slow peptidyl-prolyl isomerization of proteins, allowing relaxation of local energetically unfavorable conformational states … WebHowever, the role of Pin1 in cancer remains enigmatic as the gene is located on chromosome 19p13.2, which is a region subject to loss of heterozygosity in several tumors. Since Pin1 protein is frequently under-expressed in kidney cancer, we have explored its role in human clear cell renal cell carcinoma (ccRCC).
WebLike all plant Pin1-type PPIases, do not contain the N-terminal WW domain found in other eukaryotic parvulins, but contains a four-amino acid insertion next to the phospho-specific recognition site of the active site. ... Catalytic activity [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) EC:5.2.1.8 (UniProtKB ... WebApr 14, 2024 · The multicomponent NEC involves emerin, p32/gC1qR, protein kinase C (PKC), cyclin-dependent kinase 1 (CDK1), possibly also CDK2 and further CDKs, the viral kinase vCDK/pUL97 and the peptidylprolyl cis/trans isomerase Pin1 [16,18,19,20,21,22,23,24,25]. In particular, these kinases are of major importance for …
WebPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) specifically binds and isomerizes the phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif, which leads to changes in protein conformation and function. Pin1 is widely overexpressed in cancers and plays an important role in tumorigenesis. Mounting evidence has revealed that targeting …
WebPIN1 INFORMATION. Proteini. Full gene name according to HGNC. Peptidylprolyl cis/trans isomerase, NIMA-interacting 1. Gene namei. Official gene symbol, which is typically a … new games trailers 2014WebJun 19, 2014 · The proposed loss of PIN phosphorylation in the pid mutant has been used to explain the phenotypic similarity between pin1 and pid mutants: pin1 mutants, on the one side, have a pin-formed inflorescence because they are devoid of the central auxin efflux protein required for shoot meristem differentiation (Galweiler et al., 1998); pid mutants ... intersystems ccontrolWebJul 2, 2001 · Pin1 elevates cyclin D1 protein and activates the cyclin D1 promoter via the AP-1 site. (A) Increase in cellular cyclin D1 protein by Pin1. MCF7 or T47D cells were transfected with Pin1 or control vector, followed by immunoblotting analysis of the cell lysates with antibodies against Pin1 and cyclin D1, with actin as a control. new game studios looking to hireWebThe only reported case of alterations in the identity of the cells in the position of cotyledons is when either an apolar PIN1 protein or a dominant-negative Rab GTPase was … intersystems cambridge maWebPin1 Protein Overview. Peptidyl-prolyl cis/trans isomerases (PPIases; EC 5.2.1.8), such as PIN1, catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. PIN1 is the … new game sublettingWebDec 11, 2024 · However, in the pin1;pPIN1::PIN2 transgenic line we constructed, when PIN2 was ectopically expressed in the stele cells under the control of Arabidopsis PIN1 promoter , it was localized to the basal side of the stele cells to direct auxin flow towards the root tip like PIN1 protein does (Fig. 3, C and E). new games \u0026 sportsWebJun 1, 2024 · First, 5 µg of purified Pin1 protein in 50 µl of 20 mM HEPES pH 7.5 and 75 mM NaCl was incubated with 5 µM of respective Pin1 inhibitors for 0–3 h. A Shimadzu XR HPLC device was used to ... new games trending