WebbLeg cramps and calf muscle pain at night are very common. Deep vein thrombosis (DVT): In rare cases, what seems like calf muscle pain can actually be DVT. This is a serious … Webb22 feb. 2024 · Hamstring and Calf Tightness Tightness in the muscles on the back of your thigh and calf can lead to pain with straightening out your knee. This tightness can happen for many reasons including a protective reaction to a new injury and prolonged positioning of the knee in a bent position.
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